The commercial real estate of Minnesota is concentrated on the twin cities of Minneapolis and St. Paul.

Minneapolis is the largest city in Minnesota, as well as the seat of Hennepin County. It is situated in the southeast central part of Minnesota, on the Mississippi River. It flanks its twin city of St. Paul. Minneapolis is a major hub of commerce and industry, and serves a large agricultural region. During the 1900s, manufacturing, milling, food processing, health services, computers, and graphic arts grew as the citys major industries. There are fifteen Fortune 500 companies that have their headquarters in the Minneapolis and St. Paul metropolitan area. The Ninth Federal Reserve Banks headquarters is also located in the city.

Also, the twin cities are famous for their broad range of cultural appeal, and there are many historical museums in Minneapolis. They include the Walker Center, the Minneapolis Institute of Arts, and the Frederick R. Weisman Art Museum, which is located at the University of Minnesota's Minneapolis campus.

St. Paul has a population of over 270,000, and is smaller than Minneapolis. It lies along the Mississippi River, adjacent to Minneapolis, forming the metropolitan area of the twin cities. St. Paul is a port of entry in the Mississippi, in addition to being a railroad hub. The city is a financial, commercial, and industrial center. St. Paul also shares an international airport with its twin. Among the city's various industries are construction, electrical and medical equipment, paper and plastic products, sheet metal, motor vehicles, food and consumer goods. Other industries are oil refining, and printing and publishing.